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|  Texas Southern University |
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| Texas Southern University |
There is an increasing need for a more efficient health care system including novel drugs that help to relieve the health disparity in minority and urban communities. The Pharmacology Core helps TSU achieve its goal of improving biomedical research on minority health. In conjunction with the other RCMI research cores and laboratories, lead compounds can be screened and analyzed at the Pharmacology Core facility, and will be optimized and further developed to obtain preclinical efficacy, toxicity and pharmacokinetic information, and eventually translated to Phase 0-I clinical trials. The following resources are available in the Pharmacology Core facility: drug preformulation and formulation on promising compounds; novel nanotechnology-based drug formulation, characterization and delivery techniques for in vitro and in vivo studies; nanoparticle imaging and analysis instruments, and methods for molecule and particle characterization; mass spectrometry instruments and capability of qualitative and quantitative measurement of small molecules; and small animal facility for preclinical and clinical pharmacokinetics and pharmacodynamics studies.
plate reader
CytoViva’s Hyperspectral Imaging technology was specifically designed to provide quantitative spectral analysis of nanoscale materials imaged with the patented CytoViva darkfield-based microscope system or with other microscopy modalities. This can include spectral analysis of both biological and materials-based nanoscale samples, which may be isolated or integrated in cells, tissue or other materials-based matrices. CytoViva provides hyperspectral imaging in the visible near-infrared (VNIR 400nm-1,000nm) wavelength ranges as well as in the short wave infrared (SWIR 900nm-1,700nm) wavelength ranges.
scale
Precision Scientific Dubnoff Metabolic Shaker Incubator hascontrol dials for shaker speed, temperature and heater switch. There is a separate control for motor and line. A temperature gauge on the front of the unit which reads in -10 to 110C and an internal bath dimension measuring inches of 10.5 L X 11 W X 3.5 D. Unit heated to 60C within 10 minutes. S/N DEAZ-590. Approximate overall dimensions in inches is 14 L X 23 W X 13 H. Power is 120 volts and 50 / 60Hz.
It is used for quickly separating precipitates and liquids of different specific densities
It is used for quickly separating precipitates and liquids of different specific densities
It is used for quickly separating precipitates and liquids of different specific densities
The Tosoh G8 HPLC Analyzer utilizes the Gold Standard Ion-Exchange method of HbA1c measurement.
Rotary Evaporator
The Fisher Scientific Isotemp 210 Water Bath is a microprocessor controlled water bath with a digital control/readout, volume 10 L, temperature up to 99.9°C, temperature uniformity 0.24°C at 37°C, stability 0.5°C at 37°C, 115 V.
Programmable microprocessor control provides reliable sample protection, excellent energy efficiency, and low noise levels.
Ideal for storing nonvolatile reagents, samples, and specimens.
KrosFlo Research IIi Tangential Flow Filtration (TFF) System is the ideal system for small volume, R&D scale microfiltration and ultrafiltration. Processing volumes range from 1 ml to 10 L The system consists of the KrosFlo Research IIi Pump and Pump Head, with an integrated KrosFlo Digital Pressure Monitor, KF Comm Data Collection Software, Disposable flow-path kit and Fittings kit, all of which have features that ensure efficient and reproducible Tangential Flow Filtration processing. The system has flow rates from 0.01 to 2300 ml/minute with one pump head and up to 3800 ml/min with two pump heads. The system has both audible and visual low and high pressure alarms for the inlet and permeate and a high-pressure pump shutoff that helps maintain membrane integrity and achieve high product recovery.
Provide speed, sensitivity, resolution, and reliability for your routine or complex LC-MS/MS analysis.
To speed up R&D in such areas as pharmacokinetics (drug manufacturing), it has become increasingly necessary to analyze large numbers of samples at high speed and high precision. In response to these demands, the new Nexera MP Ultra High Performance Liquid Chromatograph utilizing the SIL-30ACMP Multiplate Autosampler was developed. The SIL-30ACMP achieves an ultrafast injection performance exceeding that of current models while maintaining ultralow carryover performance. In addition, up to 6 microtiter plates can be loaded, enabling a maximum of 2304 samples to be analyzed continuously. By incorporating these various functions, the Nexera MP is ideally suited as a front-end LC for LC/MS and LC/MS/MS systems.
These microprocessor controlled units feature a front-facing control panel with an easy-to-read LED that displays set-point temperature. Enhanced electronics regulate the robust heater, which brings samples to the desired temperature quickly and efficiently. Speed is precisely controlled, and provides consistent stirring at all speeds. The low profile design utilizes minimal bench space and permits use within a fume hood.
dynamic light scattering for size and zeta potential measurement
Minilys is a compact tissue homogenizer. Easy to place anywhere on the bench, it is the best solution for daily applications. The Minilys' flexibility allows for the homogenization of soft and hard samples up to 5000mg.
A balance line featuring ergonomic design, a brilliant display, a clear user interface, multiple built-in applications, battery operation for full mobility, and of course, good weighing performance and robustness.
Provides a stable in-vitro growth environment by heating chamber walls utilizing water.
The Parker Balston NitroFlow Lab is a self contained generator that produces up to 32 lpm of pure LC/MS grade nitrogen at pressures up to 8 bar.
Laboratory oven.
Ideal for a wide range of laboratory measurements such as pH, ion-selective, and ORP. Convenient display guides you from calibration through sample measurements--simply press the YES or NO keys in response to prompts. Select from three resolution levels according to your needs--fast results at 0.1 pH unit to precise results at 0.001 pH unit. Meters display either pH, mV, or concentration and temperature simultaneously.710A pH/ION meter provides fast accurate results at an economical price—perfect for most ISE measurements. Access all functions via the custom LCD and the eight-button, sealed membrane keypad. Meter includes an ORION ROSS combination pH electrode 05718-02 and an AC adapter.
General purpose, flammable material storage, explosion-proof, and dual-temperature refrigerator and freezer combinations offer temperature security solutions while meeting your applications storage needs.
General purpose, flammable material storage, explosion-proof, and dual-temperature refrigerator and freezer combinations offer temperature security solutions while meeting your applications storage needs.
Screening data analysis
Manual sampling or simple integration into an automated system.
Monitoring device.
high performance UV-Vis-NIR spectrophotometer with superb photometric performance in the 175-1500 nm range.
Provides fast and efficient mixing with minimal vibration
Advanced hot plate stirrers are designed to deliver accurate and repeatable results in general-purpose laboratory applications. These microprocessor controlled units feature a front-facing control panel with an easy-to-read LED that displays set-point temperature. Enhanced electronics regulate the robust heater, which brings samples to the desired temperature quickly and efficiently. Speed is precisely controlled, and provides consistent stirring at all speeds. The low profile design utilizes minimal bench space and permits use within a fume hood. Unit housing is constructed of a heat- and chemical-resistant polymer that remains cool to the touch during operation. The spill-resistant design channels fluids away from internal components in the event of spills.
120V, 50/60Hz, 75W. Variable speed control of 100-3200rpm for gentle shaking to vigorous vortexing. Continuous or touch mode. Three-way power switch and speed knob with variable 1 to 10 dial marks. With cup head and 7.6cm head with cover. Dimensions: 12.2Wx17.3Dx12.2Hcm.
120V, 50/60Hz, 75W. Variable speed control of 100-3200rpm for gentle shaking to vigorous vortexing. Continuous or touch mode. Three-way power switch and speed knob with variable 1 to 10 dial marks. With cup head and 7.6cm head with cover. Dimensions: 12.2Wx17.3Dx12.2Hcm.
oven
Drying ovens are ideal for sterilization, drying, and thermal storage tasks which do not require high drying rates or special time parameters.
The Waters 2487 Dual λ Absorbance Detector is the most sensitive and versatile absorbance detector for HPLC. Designed to provide the highest performance in UV/Vis detection, the 2487 offers the superior sensitivity required for detection of minor impurities with the linear dynamic range to simultaneously quantitate major and minor components for both routine and complex HPLC applications.
The Waters 600E system is a high-performance liquid chromatography (HPLC) multisolvent delivery system. The time proven solvent delivery design provides unmatched reliability, which means less maintenance and maximum up time. Use the Waters 600S controller with PowerLine software for auto sampler and detector control.
Waters 600 Pump with stainless steel flow path features 50 ul pump head volume, maximum pressure 5000 psi (351.5 kg/cm2) and 0.01 to 5.0 ml/min operating flow rate. The waters 600E Multisolvent Delivery System offers no-compromise performance in a true single pump design. By combining two Waters patented technologies - time-proven solvent delivery and our innovative Random Phase Synchronization (RPS) software - the 600E Multisolvent Delivery System offers you unmatched performance compared with any other single pump gradient system.
An autosampler is a versatile, compact sample management system that makes highly precise and reproducible injections of samples into your LC or LC/MS system. It is ideally suited for laboratories where reduced carryover, maximized repeatability, high accuracy, and application flexibility are of concern.
An autosampler is a versatile, compact sample management system that makes highly precise and reproducible injections of samples into your LC or LC/MS system. It is ideally suited for laboratories where reduced carryover, maximized repeatability, high accuracy, and application flexibility are of concern.
Liquid chromatography can be performed using planar or column techniques . Column liquid chromatography is the most powerful and has the highest capacity for sample. In all cases, the sample first must be dissolved in a liquid that is then transported either onto, or into, the chromatographic device
Liquid chromatography can be performed using planar or column techniques . Column liquid chromatography is the most powerful and has the highest capacity for sample. In all cases, the sample first must be dissolved in a liquid that is then transported either onto, or into, the chromatographic device.
Features an integrated, high-pressure, binary HPLC pumps that feature on-board pulse dampening and efficient mixing. Their pulse-free solvent flow, from analytical to semi-preparative flow rates, makes them ideal for use with highly sensitive detectors.
Designed for use with 2 to 4.6 mm I.D. columns in routine LC and LC/MS applications, these pumps have a programmable flow-rate range of 0.00 to 10.00 mL/min in 0.01 mL increments.
The In-Line Degasser AF removes dissolved gases from samples, which is a necessary step for obtaining accurate readings in HPLC. It features a zero hysteresis/constant-run vacuum pump with a stepper motor for membrane degassing of HPLC mobile phases
The Waters 2998 Photodiode Array (PDA) Detector offers advanced optical detection, providing unprecedented trace impurity detection and quantitation in conjunction with spectral analysis capabilities.
The Waters 2998 Photodiode Array (PDA) Detector offers advanced optical detection, providing unprecedented trace impurity detection and quantitation in conjunction with spectral analysis capabilities.
High levels of sensitivity and specificity make fluorescence an increasing favorable mode of detection for HPLC. Waters 474 Fluorescence detector with advanced programming and scanning capabilities surpasses the previous standard for sensitivity set by the 470 detector.
A dual range semi-micro balance allowing weighing at different resolutions
TurboVap® LV Concentration Evaporator Workstation provides simultaneous evaporation of up to 50 samples. This evaporation system offers many interchangeable tube racks giving you the flexibility for automated low volume sample preparation ranging in volumes size from 1.5 mL to 30 mL.